Microscopy Research & Development @ SAGLO

Method Development

While state-of-the-art Optical microscopy techniques are extremely powerful, some research problems require dedicated method development to answer challenging structural or functional questions.

We are focusing on three main methodology areas in response to the needs of our collaborations partners, developing approaches for dedicated structural and functional analysis of materials at the atomic or nanoscale.

Research

SAGLO is committed to furthering R&D while advancing technological innovation to ensure the creation of novel manufacturing technologies and new solutions to a variety of issues. Also, in order to highlight advanced technical capabilities and corporate value based on SAGLO’s opto-electronics and precision technologies for microscope. Super-resolution nonlinear fluorescence microscopy which is lower cost and more convenient than conventional super-resolution microscopy to meet demands for observing deep areas, is under development.

Basic Technologies

SAGLO continue basic R&D activities based on a long-term perspective. SAGLO is conducting R&D in a wide range of technologies, such as optics, precision microscopic measurement and manufacturing, image processing, materials, and software and systems.

R&D Organizations

SAGLO is conducting R&D in each business including the Research & Development Division for basic R&D, the Optical Microscopy Engineering Division for optical design technology development, the Next Generation Project Division that conducts R&D in order to realize growth strategies, the Production Technology Division for production technological development, the Imaging Product Business, the Precision Equipment Business and the Healthcare Business. By associating research and development with each business/division, SAGLO’s reliable technology is more effectively nurtured.

Current Projects (Jun 2023 to Jan 2024) –

SAGLO Microscopic Reporting Software-

This software under development by our Research Team – Anuja Gavade, Saloni More etc

It covers all microscopic reporting as per 21 CFR –

SAGLO Internal Audit and billing Reporting Software-

This software under development by our Research Team – soyam Vanmore and his team etc

Current Projects (Jan 2022 to May 2024) –

Light Sheet Fluorescence Microscopy with 455nm Laser Adapter Diode at 45 degree angle Illumination or Super Resolution Microscopy by 455nm Laser Adapter Diode at 45 degree angle Illumination.

Abstract- Lattice light-sheet microscopy is a modified version of light sheet fluorescence microscopy that increases image acquisition speed while decreasing damage to cells caused by phototoxicity. This is achieved by using a structured light sheet to excite fluorescence in successive planes of a specimen, generating a time series of 3D images which can provide information about dynamic biological processes. Our Team stated that goal is to combine work on microscopy to develop a “high-speed, high-resolution, low-impact tool that can look deep inside biological systems.” Penetration deeper than 20-100 μm may be achieved by combining lattice light-sheet microscopy with adaptive optics.

2. Nanoparticle analyzed by high-resolution dark-field nanoscopy image by chromatic contrast enhancement at 660nm.

Abstract-The Super-resolution imaging in dark field nanoscopy at 660nm laser illumination become a the imaging acquisition techniques for single-molecular localization. High-resolution dark-field nanoscopy by chromatic contrast enhancement illumination system at 660nm that allows the condenser to provide the central background color exclusively while a special fiber optic illuminator in the stage provides a nearly horizontal oblique contribution of the contrasting color 360 degrees around the vertical light path. Gold nanoparticle visualised by beyond diffraction-limited spots on a dark background.

Copyright by SAGLO Research Reprinting and copy is stickily prohibited

Indian Copyright Application No.-14795-2022-COL

Projects Completed (Till Date) –

SAGLO Microscopic Analysis Software- SAGLO Soft version 1

This software developed by Vishwa Technology, Karad -Director -Aviraj Nikewadi

It covers all microscopic image aquisition, reporting, image processing etc

SAGLO® Soft Software and Digital Micro Imaging Adaptor can be widely used in medical clinical examination, teaching, in colleges, universities and scientific researchers. SAGLO® Soft Software contain wide ranges of optional accessories provides multipurpose such as phase contrast observation, Bright and dark field observation, microphotography, image processing, particle size determination in μm, pathological report and patient manager, microphotograph, recording mobility video, drawing and labeling etc. The outstanding design of SAGLO® Soft Software helps the research work and convenient in biology, histology, pathology and pharmaceutical field.

SAGLO Microscopic Analysis Software- SAGLO Soft version 2

This software developed by Logisoft Technology, Kolhapur –

It covers all microscopic image aquisition, reporting, image processing, 3d analysis of particle or microscopic image etc

SAGLO Soft Software and Digital micro-imaging Adaptor with Microscope Cited in Research paper published by Scientist’s or Phd Scholars or Professors

Kulkarni, A. S. ; Bhujbal, S. S., Design and development of microparticulate delivery system for curcumin. Pharmacognosy Research 2019 Vol.11 No.3 pp.321-328. http://Kulkarni, A. S. ; Bhujbal, S. S., Design and development of microparticulate delivery system for curcumin. Pharmacognosy Research 2019 Vol.11 No.3 pp.321-328.
Shrishail M. Ghurghure et.al. Design and development of anti-aging potential of polyherbal cream containing Punica granatum seed oil. IJCRT | Volume 8, Issue 9 September 2020. https://www.ijcrt.org/papers/IJCRT2009424.pdf
Shrishail M. Ghurghure et.al. Fabrication And Evaluation Of Simvastatin Nano Sponges For Oral Delivery, Indo American Journal of Pharmaceutical Research.2019:9(04). http://ijrar.com/upload_issue/ijrar_issue_20543961.pdf
T. S. Shikalgar et.al, Evaluation Of Cardioprotective Activity Of Fulvic Acid Against Isoproterenol Induced Oxidative Damage In Rat Myocardium,Int. Res. J. Pharm. 2018, 9 (1). https://www.irjponline.com/admin/php/uploads/2876_pdf.pdf
Shirish Patil et.al, The Cardioprotective Effect Of Argemone Mexicana On Doxorubicin Induced Cardiotoxicity In Rats, IAJPS 2018, 05 (09),8884-8894, http://doi.org/10.5281/zenodo.1421351.
Manure JY et.al, A New Types of Polymorphic Form of 10-Propargyl-10-Deazaaminopterin, from SL: As a Refractory Peripheral T-cell Lymphoma Drug; PharmaTutor; 2018; 6(4); 45- 50; https://www.pharmatutor.org/articles/a-new-types-of-polymorphic-form-of-10-propargyl-10-deazaaminopterin-from-sl-as-a-refractory-peripheral-t-cell-lymphoma-drug
Pratik Maske et.al, Pharmacognostic Profiling of Spermadicyton suaveolens Root, Ijppr.Human, 2022; Vol. 23 (3): 237-247.https://ijppr.humanjournals.com/wp-content/uploads/2022/03/18.Pratik-Maske-Popat-Kumbhar-Ashok-Wali-John-Disouza-Maya-Sharma.pdf
Ashapak Tamboli et.al, Physicochemical, Pharmacognostical And Phytochemical Analysis Of Leaves Extract Of Mimosa Rubicaulis (Lam), IJBPAS, August, 2021, 10(8): 2649-2660. https://doi.org/10.31032/IJBPAS/2021/10.8.5569.
Ashok A. Muchandi et.al, Protective effects of ethanolic extract of Piper cubeba L. on D-galactose induced neuronal lipofuscinogenesis in albino rats, Science, Engineering and Health Studies 2018, 12(1), 11-17.https://www.thaiscience.info/Journals/Article/SEHS/10989775.pdf
Rakesh Mishra1*, Shweta Kulkarni2, Akash Aher3 One Pot Development Of Lipid-Based Quercetin Spherical Agglomerates For Bioavailability Enhancement: In Vitro And In Vivo Assessments, Int J App Pharm, Vol 15, Issue 3, 2023, 168-177. https://journals.innovareacademics.in/index.php/ijap/article/view/47266/28079
Mrs. Anuradha U. Bhoi, 2mr. Udaykumar A. Bhoi, 3mrs. Manisha V. Mane, 4 Mr. Avadhut P. Jadhav, 5dr. Pravin S. Patil Formulation And Evaluation Of Topical Drug Delivery For Wound Healing In Diabetics Patients, International Journal Of Creative Research Thoughts, Volume 10, Issue 11 November 2022. https://ijcrt.org/papers/IJCRT2211397.pdf

Research Paper Published in Scientific Journal By SAGLO R & D

Sachin, Lokapure (June 2020). “Motiloscope- A Novel Method and Device to Detect Bacterial Motility using Disk Type Sample Holder” (PDF). International Research Journal of Engineering and Technology. 07: 2265.
Sachin Lokapure (May 2022), Nanoparticle analyzed by high-resolution dark-field nanoscopy image by chromatic contrast enhancement at 660nm, Applied Microscopy (In press)

Will update soon………..

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Utility Patent Granted By SAGLO Research

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